As a result of the recent pandemic, global value chains have completely transformed. This has raised concerns over the ensuing social, economic and environmental trends and related impact on the way supply chains are organised. In this context, the EU-funded ReSChape project will analyse social, economic and environmental changes and disruptions, including the COVID-19 pandemic, and evaluate their impact on supply chains. New supply chain models will be proposed, aiming towards a more streamlined supply chain process to assure humans (workers, consumers and in general citizens) to be at the center of the business also thanks to new digital technologies. It will be studied how to assure a positive social impact and innovative policy scenarios will be developed with recommendations to support the future supply chains.