loader image
Skip to main content

Container Logistics

Proteolysis targeting chimeras (protein degraders) represent an innovative approach in drug discovery, leveraging bifunctional molecules to promote targeted protein degradation by linking target proteins to E3 ubiquitin ligases. Despite their promise, the development of protein degraders poses significant challenges:

Physicochemical Properties: Protein degraders, with molecular weights between 900-1,100 Da and increased polar surface area, often exhibit poor cell permeability, metabolic instability, and low oral bioavailability.

Optimization Complexity: Designing effective linkers and ligands requires balancing stability, solubility, and binding efficiency, while simultaneously enhancing PK and PD profiles.

Related tags:

User interests tagged with "Container Logistics"

  • Giannis KanellopoulosGiannis Kanellopoulos
  • Miguel Ortega-MierMiguel Ortega-Mier
  • Achim KlukasAchim Klukas
  • NHNiek Hacquebord
  • Scutelnicu PetruScutelnicu Petru
  • EREckhard Rautenberg
  • NKNils-Olaf Klabunde
  • PPPedro Perez
  • Frank ReijerseFrank Reijerse
  • logo SLP AllianceJoris Claeys
  • SSShiqi Sun
  • Alejandro HerraezAlejandro Herraez
  • Claire JosquinClaire Josquin
  • Sotiris profileSotirios Ptochos
  • Milan SunaricMilan Sunaric
  • Marianna LevtovMarianna Levtov
  • Gadi BenmosheGadi Benmoshe
  • Silvia DoplerSilvia Dopler
  • KONSTANTINOS HANIOTISKONSTANTINOS HANIOTIS
  • Janne LausvaaraJanne Lausvaara
  • Eduardo PereaEduardo Perea
  • EBErnst Brudna
  • Cristian AlcácerCristian Alcácer
  • Claudio SalvadoriClaudio Salvadori