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The concept of Hyperconnected City Logistics (HCL) suggests an open and shared system associate with multi-modes transportation to meet the challenges of City Logistics (CL). A new application of Parcel lockers is suggested in this paper which is to be used as transhipment hubs besides the current popular utilization as ship/reception lockers. Transhipment could be easily processed through parcel lockers rather than building new specific transfer hubs which are cost consumption and normally away from demand nodes. We formulate the model from the perspective of Pick-up and Delivery Problem with Transhipment and Time-Window (PDPTTW) and propose Combine Saving heuristic for solving the PDPTTW. The heuristics has been evaluated by a set of examples and show a good performance.