In this paper, we present a dynamic approach for designing a hyper-connected network based on the multi-plane logistic structure proposed by Montreuil, Shannon, et al. (2018). Possible hub candidates are selected based on geographical locations and historic demand volume, and a heuristic solution for large-scale hub location problem (up to 5000 nodes) is presented to reflect different consolidation preference. Moreover, we construct an end-to-end framework for network configuration assessment and update through routing and simulation, allowing optimization of the whole system over comprehensive performance indicators.